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THE CORD BLOOD TRANSPLANTATION STUDY (COBLT) is a prospective safety and efficacy study of umbilical cord blood stem and progenitor cell transplantation. The main objectives of the study are to determine if umbilical cord blood is a useful source of stem cells for hematopoietic reconstitution. In patients with malignancy, the study will determine if there is a cell dose per recipient weight which is limiting and if the two HLA mismatch barrier may be crossed by using cord blood as the source of hematopoietic stem cells. The study is funded by the National Heart, Lung and Blood Institute (NHLBI).
 
Among other criteria, patients for the study must have leukemia, hematologic disorder, or metabolic disorder acceptable for transplant.
 
The COBLT Study is being conducted at the following Clinical Transplant Centers. To find out more about each transplant center, click on a name to access the center's web page.
 
Cardinal Glennon Children's Hospital
Case Western Reserve University Hospital /Ireland Cancer Ctr
Children's Hospital of Los Angeles
Children's Hospital of New Orleans
Children's Hospital of Orange County
Children's Hospital of Philadelphia
Children's Hospital of Pittsburgh
Children's Medical Center of Dallas
Children's Mercy Hospital
Children's National Medical Center
City of Hope National Medical Center
Dana Farber Cancer Institute
DeVos Children's Hospital
Duke University Medical Center
Fred Hutchinson Cancer Research Center
Hackensack University Medical Center
Indiana University Cancer Center
Schneider Children's Hospital
North Texas Hospital for Children
Roswell Park Cancer Institute
Texas Transplant Institute
University of California-Los Angeles
University of California-San Francisco
University of Florida/ Shands Hospital
University of Minnesota
University of Rochester Medical Ctr/Strong Memorial Hospital
Vanderbilt-Ingram Cancer Center

There are two cord blood banks funded by NHLBI designated to  collect cord blood units as part of this project. Collection  of umbilical cord blood for use by this study will only take  place at hospitals associated with these cord blood banks.  Please refer to the websites below for more information about donating  umbilical cord blood.
 
Umbilical cord blood units will be collected by the following banks.
To find out more about each cord blood bank, click on a name to access the bank's web page.
 
Carolinas Cord Blood Bank-Duke University
University of California-Los Angeles Cord Blood Bank
 
 
For additional information regarding the study, please contact one of the participating clinics, or feel free to contact the NHLBI Project Officer, Luiz Barbosa, D.V.M., at 301-435-0080.