The Cord Blood Transplantation Study Home Page

NEWSLETTERS COBLT ROSTER (PDF) PRESENTATIONS MANUALS Transplant Center Manual of Procedures (MOP) Transplant  Center Protocol Expanded  Access Protocol (EAP) Cord  Blood Bank Standard Operating Procedures (SOP)  Search System User's Guide MANUAL AMENDMENT MOP Amendment 5 Protocol Amendment 7 EAP Amendment 2 SOP Amendment 5 RELATED SITES American Association of Blood Banks (aaBB) The International Society for Hematotherapy and Graft  Engineering (ISHAGE) Foundation for the Accreditation of Hematopoietic Cell Therapy  (FAHCT) National Heart, Lung, and Blood Institute (NHLBI) National Marrow Donor Program (NMDP) NIH News release announcing start of COBLT  study Statement from Dr. L'Enfant

THE CORD BLOOD TRANSPLANTATION STUDY (COBLT) is a prospective safety and efficacy study of umbilical cord blood stem and progenitor cell transplantation. The main objectives of the study are to determine if umbilical cord blood is a useful source of stem cells for hematopoietic reconstitution. In patients with malignancy, the study will determine if there is a cell dose per recipient weight which is limiting and if the two HLA mismatch barrier may be crossed by using cord blood as the source of hematopoietic stem cells. The study is funded by the National Heart, Lung and Blood Institute (NHLBI).   Among other criteria, patients for the study must have leukemia, hematologic disorder, or metabolic disorder acceptable for transplant.   The COBLT Study is being conducted at the following Clinical Transplant Centers. To find out more about each transplant center, click on a name to access the center's web page.   Cardinal Glennon Children's Hospital Case Western Reserve University Hospital /Ireland Cancer Ctr Children's Hospital of Los Angeles Children's Hospital of New Orleans Children's Hospital of Orange County Children's Hospital of Philadelphia Children's Hospital of Pittsburgh Children's Medical Center of Dallas Children's Mercy Hospital Children's National Medical Center City of Hope National Medical Center Dana Farber Cancer Institute DeVos Children's Hospital Duke University Medical Center Fred Hutchinson Cancer Research Center Hackensack University Medical Center Indiana University Cancer Center Schneider Children's Hospital North Texas Hospital for Children Roswell Park Cancer Institute Texas Transplant Institute University of California-Los Angeles University of California-San Francisco University of Florida/ Shands Hospital University of Minnesota University of Rochester Medical Ctr/Strong Memorial Hospital Vanderbilt-Ingram Cancer Center There are two cord blood banks funded by NHLBI designated to  collect cord blood units as part of this project. Collection  of umbilical cord blood for use by this study will only take  place at hospitals associated with these cord blood banks.  Please refer to the websites below for more information about donating  umbilical cord blood.   Umbilical cord blood units will be collected by the following banks. To find out more about each cord blood bank, click on a name to access the bank's web page.   Carolinas Cord Blood Bank-Duke University University of California-Los Angeles Cord Blood Bank     For additional information regarding the study, please contact one of the participating clinics, or feel free to contact the NHLBI Project Officer, Luiz Barbosa, D.V.M., at 301-435-0080.